Seasonal dynamics of recombinant lactoferrin concentration in milk of transgenic goats
Abstract
Recombinant lactoferrin produced by the mammary gland of transgenic goats corresponds to the native protein in its structure and functional activity, retaining all its biological properties. Long-term studies have established some effect of genetic modification and seasonal variations on the composition of milk of transgenic animals. These factors must be considered in the long-term housing of a dairy herd and the development of technologies for processing milk with certain biotechnological properties. This paper contains the results of analyzing the seasonal dynamics of recombinant lactoferrin content in the milk of transgenic goats during a three-year monitoring period. In the course of studies conducted during 2022-2024, pronounced seasonal variations with a tendency to decrease the protein level in the spring-summer period were established. In 2022, the lowest variability of indicators was observed (2.8-3.0 g/l) with minimal deviations compared to 2023 and 2024. The identified interseasonal differences indicate the influence of the season on the synthesis of rLF.
About the Author
E. V. Petrushko
Scientific and Practical Center of the National Academy of Sciences of Belarus for Animal Breeding
Belarus
Belarus
Zhodino
References
1. Lactoferrin: Structure, function, denaturation and digestion / B. Wang, Y. P. Timilsena, E. Blanch [et al.] // Crit. Rev. Food Sci. Nutr. – 2019. – Vol. 59(4). – P. 580-596. – DOI: 10.1080/10408398.2017.1381583.
2. The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor / Y. Hu, X. Meng, F. Zhang [et al.] // Emerg. Microbes Infect. – 2021. – Vol. 10. – P. 317-330. – DOI: 10.1080/22221751.2021.1888660.
3. Superti, F. Lactoferrin from Bovine Milk: A Protective Companion for Life / F. Superti // Nutrients. – 2020. – Vol. 12(9). – P. 2562. – DOI: 10.3390/nu12092562.
4. Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections / M. E. Drago-Serrano, R. Campos-Rodríguez, J. C. Carrero [et al.] // Int. J. Mol. Sci. – 2017. – Vol. 18. – P. 501. – DOI: 10.3390/ijms18030501.
5. Antioxidant Potential of Lactoferrin and Its Protective Effect on Health : An Overview / Q. Rascón-Cruz, T. S. Siqueiros-Cendón, L. I. Siañez-Estrada [et al.] // Int. J. Mol. Sci. – 2024. – Vol. 26(1). – P. 125. – DOI: 10.3390/ijms26010125.
6. The lactoferrin phenomenon – a miracle molecule / P. Kowalczyk, K. Kaczyńska, I. Bukowska-Ośko [et al.] // Molecules. – 2022. – Vol. 27. – P. 2941. – DOI: 10.3390/molecules27092941.
7. Lactoferrin Market By Application, Form, Source, and End-use – Global Forecast to 2030 // Market&Market. – URL: https://www.marketsandmarkets.com/Market-Reports/lactoferrin-market-91627561.html (date of access: 10. 02. 2025).
8. Factors Affecting the Lactoferrin Concentration in Bovine Milk / J. B. Cheng, J. Q. Wang, D. P. Bu [et al.] // Journal of Dairy Science. – 2008. – Vol. 91(3.) – P. 970-976. doi: 10.3168/jds.2007-0689.
9. Current practices with commercial scale bovine lactoferrin production and alternative approaches / E. Krolitzki, S.P. Schwaminger, M. Pagel [et al.] // International Dairy Journal. – 2022. – Vol. 126. – DOI: 10.1016/j.idairyj.2021.105263
10. Получение рекомбинантного лактоферрина человека из молока коз-продуцентов и его физиологические эффекты / В. С. Лукашевич. А. И. Будевич, И. В. Семак [и др.] // Докл. Нац. акад. наук Беларуси. – 2016. – Т. 60, № 1. – С. 72–81.
11. Влияние сезона года и лактации на состав молока коз–продуцентов биоаналога лактоферрина человека / А. И. Будевич, Е. В. Петрушко, Д. М. Богданович [и др.] // Вестник НГАУ. – 2021. - № 1. – С. 81-91.
12. Мониторинг уровня продукции рекомбинантного лактоферрина человека в молоке генномодифицированных коз при длительной лактации / Е. В. Петрушко, Д. М. Богданович, А. И. Будевич [и др.] // Зоотехническая наука Беларуси : сб. науч. тр. – Жодино, 2020. – Т. 55, ч. 2. – С. 255-262.
Review
For citations:
Petrushko E.V. Seasonal dynamics of recombinant lactoferrin concentration in milk of transgenic goats. Zootechnical Science of Belarus. 2025;60(2):155-161. (In Russ.)
Views:
18
Email this article 