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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zootech</journal-id><journal-title-group><journal-title xml:lang="ru">Зоотехническая наука Беларуси</journal-title><trans-title-group xml:lang="en"><trans-title>Zootechnical Science of Belarus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0134-9732</issn><publisher><publisher-name>Научно-практический центр Национальной академии наук Беларуси по животноводству</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">zootech-1499</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТЕХНОЛОГИЯ ПРОИЗВОДСТВА, ЗООГИГИЕНА, СОДЕРЖАНИЕ</subject></subj-group></article-categories><title-group><article-title>ФИЗИКО-ХИМИЧЕСКИЕ ПОКАЗАТЕЛИ МОЛОКА КОЗ-ПРОДУЦЕНТОВ РЕКОМБИНАНТНОГО ЛАКТОФЕРРИНА ТРЕТЬЕГО И ЧЕТВЁРТОГО ГОДА ЛАКТАЦИИ</article-title><trans-title-group xml:lang="en"><trans-title>PHYSICAL AND CHEMICAL PARAMETERS OF MILK OF GOATS PRODUCING RECOMBINANT LACTOFERRIN OF THE THIRD AND FOURTH YEAR OF LACTATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будевич</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Budevich</surname><given-names>A. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богданович</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogdanovich</surname><given-names>D. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрушко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrushko</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заремба</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaremba</surname><given-names>N. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-практический центр Национальной академии наук Беларуси по животноводству</institution></aff><aff xml:lang="en"><institution>Research and Production Center of the National Academy of Sciences of Belarus for Livestock Breeding</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>17</day><month>08</month><year>2022</year></pub-date><volume>54</volume><issue>2</issue><fpage>141</fpage><lpage>147</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Будевич А.И., Богданович Д.М., Петрушко Е.В., Заремба Н.Л., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Будевич А.И., Богданович Д.М., Петрушко Е.В., Заремба Н.Л.</copyright-holder><copyright-holder xml:lang="en">Budevich A.I., Bogdanovich D.M., Petrushko E.V., Zaremba N.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://zootech.belal.by/jour/article/view/1499">https://zootech.belal.by/jour/article/view/1499</self-uri><abstract><p>Установлены достоверные (Р&lt;0,01; 0,001) различия по физико-химическим показателям молока между животными-продуцентами лактоферрина человека и нетрансгенными козами третьего и четвёртого года лактации.</p></abstract><trans-abstract xml:lang="en"><p>Reliable (P&lt;0.01; 0.001) variations in physicochemical parameters of milk were determined between animals producing human lactoferrin and non-transgenic goats of the third and fourth year of lactation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>козы-продуценты</kwd><kwd>лактоферрин</kwd><kwd>молоко</kwd><kwd>физико-химические показатели</kwd><kwd>producing goats</kwd><kwd>lactoferrin</kwd><kwd>milk</kwd><kwd>physical and chemical parameters</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kues, W. The contribution of farm animals to human health / W. Kues, H. Niemann // Trends in biotechnology. - 2004. - Vol. 22. - P. 286-294.</mixed-citation><mixed-citation xml:lang="en">Kues, W. The contribution of farm animals to human health / W. Kues, H. Niemann // Trends in biotechnology. - 2004. - Vol. 22. - P. 286-294.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts / A. Schnieke [et al.] // Science. - 19970. - Vol. 278. - P. 2130-2140.</mixed-citation><mixed-citation xml:lang="en">Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts / A. Schnieke [et al.] // Science. - 19970. - Vol. 278. - P. 2130-2140.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow / D. Salamone [et al.] // J. Biotechnol. - 2006. - Vol. 124(2). - P. 469-472.</mixed-citation><mixed-citation xml:lang="en">High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow / D. Salamone [et al.] // J. Biotechnol. - 2006. - Vol. 124(2). - P. 469-472.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">The Large-Scale Production of Recombinant Human Serum Albumin in the Milk of Transgenic Cattle: Strategy / S. Moghaddassi [et al.] // Bio Medicine. - 2014. - Vol. 2. - P. 6-19.</mixed-citation><mixed-citation xml:lang="en">The Large-Scale Production of Recombinant Human Serum Albumin in the Milk of Transgenic Cattle: Strategy / S. Moghaddassi [et al.] // Bio Medicine. - 2014. - Vol. 2. - P. 6-19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Effect of genetic background on glycosylation heterogeneity in human antithrombin produced in the mammary gland of transgenic goats / Q. Zhou [et al.] // J.Biotechnol. - 2005. - Vol. 117. - P. 57-72.</mixed-citation><mixed-citation xml:lang="en">Effect of genetic background on glycosylation heterogeneity in human antithrombin produced in the mammary gland of transgenic goats / Q. Zhou [et al.] // J.Biotechnol. - 2005. - Vol. 117. - P. 57-72.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Transgenic expression of a variant of human tissue-type plasminogen activator in goat milk: Purification and characterization of the recombinant enzyme / J. Denman [et al.] // Biotechnology. - 2005. - Vol. 9. - P. 839-843.</mixed-citation><mixed-citation xml:lang="en">Transgenic expression of a variant of human tissue-type plasminogen activator in goat milk: Purification and characterization of the recombinant enzyme / J. Denman [et al.] // Biotechnology. - 2005. - Vol. 9. - P. 839-843.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Induction of human tissue plasminogen activator in the mammary gland of transgenic goats / K. Ebert [et al.] // Biotechnology. - 1994. - Vol. 12. - P. 699-702.</mixed-citation><mixed-citation xml:lang="en">Induction of human tissue plasminogen activator in the mammary gland of transgenic goats / K. Ebert [et al.] // Biotechnology. - 1994. - Vol. 12. - P. 699-702.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Purification and characterization of a recombinant version of human AFP transgenic goats / M. Parker [et al.] // Biotechnology. - 2004. - Vol. 9. - P. 177-183.</mixed-citation><mixed-citation xml:lang="en">Purification and characterization of a recombinant version of human AFP transgenic goats / M. Parker [et al.] // Biotechnology. - 2004. - Vol. 9. - P. 177-183.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Production of recombinant antibodies in the milk of transgenic animals / M. Young [et al.] // Res. Immunol. - 1998. - Vol. 149. - P. 609-610.</mixed-citation><mixed-citation xml:lang="en">Production of recombinant antibodies in the milk of transgenic animals / M. Young [et al.] // Res. Immunol. - 1998. - Vol. 149. - P. 609-610.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Transgenic milk as a method for the production of recombinant antibodies / D. Pollock [et al.] // Res. Immunol. - 1999. - Vol. 231. - P. 147-157.</mixed-citation><mixed-citation xml:lang="en">Transgenic milk as a method for the production of recombinant antibodies / D. Pollock [et al.] // Res. Immunol. - 1999. - Vol. 231. - P. 147-157.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Production of recombinant spider silk (BioSteel®) in the milk of transgenic animals / C. Karatzas [et al.] // Transgenic Res. - 1999. - Vol. 8. - P. 476-477.</mixed-citation><mixed-citation xml:lang="en">Production of recombinant spider silk (BioSteel®) in the milk of transgenic animals / C. Karatzas [et al.] // Transgenic Res. - 1999. - Vol. 8. - P. 476-477.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Health and reproductive profiles of malaria antigen-producing transgenic goats derived by somatic cell nuclear transfer / E. Behboodi [et al.] // Cloning and Stem Cells. - 2005. - Vol. 7. - P. 107-118.</mixed-citation><mixed-citation xml:lang="en">Health and reproductive profiles of malaria antigen-producing transgenic goats derived by somatic cell nuclear transfer / E. Behboodi [et al.] // Cloning and Stem Cells. - 2005. - Vol. 7. - P. 107-118.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Production of biologically active human granulocyte colony stimulating factor in the milk of transgenic goat / J. Ko [et al.] // Transgenic Res. - 2000. - Vol. 9. - P. 215-222.</mixed-citation><mixed-citation xml:lang="en">Production of biologically active human granulocyte colony stimulating factor in the milk of transgenic goat / J. Ko [et al.] // Transgenic Res. - 2000. - Vol. 9. - P. 215-222.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning / Y.J. Huang [et al.] // Proc. Natl. Acad. Sci. USA. - 2007. - Vol. 104. - P. 13603-13608.</mixed-citation><mixed-citation xml:lang="en">Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning / Y.J. Huang [et al.] // Proc. Natl. Acad. Sci. USA. - 2007. - Vol. 104. - P. 13603-13608.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Expression of active recombinant human lactoferrin in the milk of transgenic goats / J. Zhang [et al.] // Protein Expr Purif - 2008. - Vol. 57(2). - P. 127-135.</mixed-citation><mixed-citation xml:lang="en">Expression of active recombinant human lactoferrin in the milk of transgenic goats / J. Zhang [et al.] // Protein Expr Purif - 2008. - Vol. 57(2). - P. 127-135.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Production of human lactoferrin in animal milk / I. L. Goldman, S. G. Georgieva, Y. G. Gurskiy, A. N. Deykin, A. N. Popov, T. G. Ermolkevich, A. I. Budzevich, A. D. Chernousov, E. R. Sadchikova // Biochem Cell Biol. - 2012. - Vol. 90(3). - P. 513-519.</mixed-citation><mixed-citation xml:lang="en">Production of human lactoferrin in animal milk / I. L. Goldman, S. G. Georgieva, Y. G. Gurskiy, A. N. Deykin, A. N. Popov, T. G. Ermolkevich, A. I. Budzevich, A. D. Chernousov, E. R. Sadchikova // Biochem Cell Biol. - 2012. - Vol. 90(3). - P. 513-519.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Large scale production of recombinant human lactoferrin in the milk of transgenic cows / H. C. Patrick van Berkel [et al.] // Nature Publishing- 2002. - Vol. 20. - P. 484-487.</mixed-citation><mixed-citation xml:lang="en">Large scale production of recombinant human lactoferrin in the milk of transgenic cows / H. C. Patrick van Berkel [et al.] // Nature Publishing- 2002. - Vol. 20. - P. 484-487.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Large-scale production of recombinant human lactoferrin from high-expression, marker-free transgenic cloned cows / Ming Wang [et al.] // Scientific Reports. - 2017. - Vol. 7. - doi:10.1038/s41598-017-11462-z.</mixed-citation><mixed-citation xml:lang="en">Large-scale production of recombinant human lactoferrin from high-expression, marker-free transgenic cloned cows / Ming Wang [et al.] // Scientific Reports. - 2017. - Vol. 7. - doi:10.1038/s41598-017-11462-z.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Recombinant human lactoferrin from transgenic goats: isolation and physicochemical properties / I. Semak [et al.] // The Xth International Conference on Lactoferrin, Structure, Function and applications, 08-12 May, 2011. - Mazatlan, Mexico. P-VI-6. - P. 74.</mixed-citation><mixed-citation xml:lang="en">Recombinant human lactoferrin from transgenic goats: isolation and physicochemical properties / I. Semak [et al.] // The Xth International Conference on Lactoferrin, Structure, Function and applications, 08-12 May, 2011. - Mazatlan, Mexico. P-VI-6. - P. 74.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Recombinant human lactoferrin expressed in transgenic goats / A. Budzevich [et al.] // The Xth International Conference on Lactoferrin, Structure, Function and applications, 08-12 May, 2011. - Mazatlan, Mexico. O-VI-2. - P. 66.</mixed-citation><mixed-citation xml:lang="en">Recombinant human lactoferrin expressed in transgenic goats / A. Budzevich [et al.] // The Xth International Conference on Lactoferrin, Structure, Function and applications, 08-12 May, 2011. - Mazatlan, Mexico. O-VI-2. - P. 66.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Характеристика физико-химических показателей молока коз-продуцентов лактоферрина человека / Е. В. Петрушко [и др.] // Зоотехническая наука Беларуси: сб. науч. тр. - Жодино, 2016. - Т. 51, ч. 2 : Технология кормов и кормления, продуктивность. Технология производства, зоогигиена, содержание. - С. 208-216.</mixed-citation><mixed-citation xml:lang="en">Характеристика физико-химических показателей молока коз-продуцентов лактоферрина человека / Е. В. Петрушко [и др.] // Зоотехническая наука Беларуси: сб. науч. тр. - Жодино, 2016. - Т. 51, ч. 2 : Технология кормов и кормления, продуктивность. Технология производства, зоогигиена, содержание. - С. 208-216.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
