The polymorphism of IGF-2 gene and its effect on the meat traits of the pigs of maternal breeds have been studied. It was determined that fattening young pigs of maternal breeds with genotype QQ of IGF-2 gene tended to superiority of animals with genotype q: in carcass length - by 0.6-1.37 %, backfat thickness - by 6.8-10.3 %, loin area - by 2.0-2.2 %, weight of rear third half-carcass - by 1.8-10.7 %. A stable positive tendency of all the meat traits increase in pigs of maternal breeds with the preferred genotypes dd and HH of the H-FABP gene was noted: in carcass length - by 2.3 %, backfat thickness - by 10.9-19.1 %, loin area - by 4.2-13.6%, weight of rear third half-carcass - by 3.2-5.6 %. It was determined that the following trend is typical for animals of maternal breeds of domestic selection (Belarusian large white, Belarusian black-motley breeds): there is a decrease in reproductive traits with the growth of meat production indices. Animals carrying in their genome the preferred genotypes BB and AB of the ESR gene, surpass their analogues with the AA genotype by reproductive traits by 11.8-0.8 %, but inferior in meat traits by 28.7-0.6 %. As for the animals of the Belarusian plant type of Yorkshire breed are characterized by both high meat and reproductive traits. This is due to breeding work carried out with the plant type, which resulted in prevalence of the preferred genotypes of ESR, IGF-2 and H-FABP genes in the animals’ genome.